\u6811\u7acb\u4e8e2010\u5e74\u3001\u603b\u90e8\u4f4d\u4e8e\u4f4d\u4e8e\u7f8e\u90a6\u9a6c\u8428\u8bf8\u585e\u5dde\u5251\u6865\u7684\u751f\u7269\u672c\u4e8b\u516c\u53f8Moderna\u662f\u6b64\u6b21\u65b0\u51a0\u80ba\u708e\uff08COVID-19\uff09\u75ab\u60c5\u4e2d\u7684\u201c\u660e\u661f\u201d\u4f01\u4e1a\u3002<\/p>\n
2020\u5e743\u670816\u65e5\uff0c\u7f8e\u90a6\u90a6\u7acb\u536b\u751f\u7b79\u8bae\u9662\uff08NIH\uff09\u516c\u544a\u5df2\u5bf9Moderna\u7814\u53d1\u7684\u75ab\u82d7mRNA-1273\u7684\u7b2c1\u671f\u7b79\u8bae\u7684\u9996\u4f4d\u51fa\u5e2d\u8005\u7ed9\u836f\uff0c\u4ece\u5e8f\u5217\u62e3\u9009\u5230\u521d\u5ea6\u4eba\u7c7b\u7ed9\u836f\u517163\u5929\u3002<\/p>\n
2020\u5e742\u670811\u65e5\uff0c\u90a6\u9645\u75c5\u6bd2\u5206\u7c7b\u59d4\u5458\u4f1a\u516c\u544a\u917f\u6210\u6b64\u6b21\u75ab\u60c5\u7684\u75c5\u6bd2\uff08\u6b64\u524d\u79f0\u4e3a\u201c2019\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u201d\uff09\u53ca\u5176\u6fc0\u52b1\u7684\u75be\u75c5\u7684\u6b63\u5f0f\u540d\u79f0\u4e3a\uff1a<\/p>\n
\u65b0\u75c5\u6bd2\u5b9a\u540d\u4e3a\u201c\u544a\u6025\u6025\u6027\u547c\u5438\u5f52\u7eb3\u5f81\u51a0\u72b6\u75c5\u6bd22\uff08SARS-CoV-2\uff09\u201d\u3002\u62e3\u9009\u8fd9\u4e00\u540d\u79f0\u662f\u7531\u4e8e\u8fd9\u4e00\u75c5\u6bd2\u4e0e\u5bfc\u81f42003\u5e74SARS\u75ab\u60c5\u7684\u51a0\u72b6\u75c5\u6bd2\u6b63\u5728\u57fa\u56e0\u4e0a\u4e92\u76f8\u76f8\u5e72\u3002\u8fd9\u4e24\u4e2a\u75c5\u6bd2\u56fa\u7136\u76f8\u5e72\uff0c\u4f46\u5374\u662f\u5206\u522b\u7684\u75c5\u6bd2\u3002<\/p>\n
\u75c5\u6bd2\u53ca\u5176\u60f9\u8d77\u7684\u75be\u75c5\u4e00\u6837\u90fd\u6709\u5206\u522b\u540d\u79f0\u3002\u6bd4\u65b9\uff0c\u4eba\u7c7b\u514d\u75ab\u7f3a\u9677\u75c5\u6bd2\uff08\u827e\u6ecb\u75c5\u6bd2\uff09\u662f\u5bfc\u81f4\u827e\u6ecb\u75c5\u7684\u75c5\u6bd2\u3002\u4eba\u4eec\u4e00\u6837\u660e\u6670\u9ebb\u75b9\uff08measles\uff09\u7b49\u75be\u75c5\u540d\u79f0\uff0c\u4f46\u4e0d\u660e\u6670\u60f9\u8d77\u8fd9\u4e00\u75be\u75c5\u7684\u75c5\u6bd2\uff08rubeola\uff09\u7684\u540d\u79f0\u3002<\/p>\n
\u75c5\u6bd2\u6309\u9057\u4f20\u673a\u5408\u5b9a\u540d\uff0c\u5982\u6b64\u505a\u7684\u597d\u5904\u662f\u4fbf\u4e8e\u8bca\u65ad\u8bd5\u5242\u3001\u75ab\u82d7\u548c\u836f\u7269\u5f00\u91c7\u3002\u75c5\u6bd2\u5b66\u5bb6\u4ee5\u53ca\u666e\u904d\u79d1\u5b66\u754c\u4eba\u58eb\u62c5\u8d1f\u6b64\u9879\u505a\u4e8b\uff0c\u56e0\u800c\uff0c\u75c5\u6bd2\u7531\u90a6\u9645\u75c5\u6bd2\u5206\u7c7b\u59d4\u5458\u4f1a\uff08ICTV\uff09\u5b9a\u540d\u3002<\/p>\n
\u800c\u75be\u75c5\u5b9a\u540d\u662f\u4e3a\u4e86\u4fbf\u4e8e\u8ba1\u5212\u75be\u75c5\u7684\u9632\u5fa1\u3001\u9f13\u5439\u3001\u9f13\u5439\u529b\u3001\u544a\u6025\u6027\u548c\u533b\u6cbb\u3002\u4e16\u536b\u6784\u5236\u62c5\u8d1f\u4eba\u7c7b\u75be\u75c5\u7684\u9632\u5fa1\u548c\u5e94\u5bf9\u505a\u4e8b\uff0c\u56e0\u800c\uff0c\u75be\u75c5\u7531\u4e16\u536b\u6784\u5236\u6b63\u5728\u300a\u90a6\u9645\u75be\u75c5\u5206\u7c7b\u300b\uff08ICD\uff09\u4e2d\u6b63\u5f0f\u5b9a\u540d\u3002<\/p>\n
\u4f9d\u7167Moderna\u5e03\u544a\u7684\u5149\u9634\u7ebf\u65e5\uff0c\u4e2d\u90a6\u5bf9\u5916\u5206\u4eab\u4e86\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u57fa\u56e0\u5e8f\u5217\u3002<\/p>\n
2020\u5e741\u670813\u65e5\uff0c\u7f8e\u90a6\u90a6\u7acb\u536b\u751f\u7b79\u8bae\u9662\uff08NIH\uff09\u548cModerna\u7684\u6d41\u884c\u75c7\u7b79\u8bae\u5c0f\u7ec4\u786e\u5b9a\u4e86\u8be5\u516c\u53f8\u9488\u5bf9\u65b0\u578b\u51a0\u72b6\u75c5\u6bd2\u7684\u75ab\u82d7mRNA-1273\u7684\u5e8f\u5217\u3002\u5f53\u65f6\uff0c\u7f8e\u90a6\u90a6\u7acb\u536b\u751f\u7b79\u8bae\u9662\uff08NIH \uff09\u7684\u90a6\u5ea6\u8fc7\u654f\u548c\u6d41\u884c\u75c7\u7b79\u8bae\u6240\uff08NIAID\uff09\u62ab\u9732\u4e86\u4ed6\u4eec\u91ce\u5fc3\u5e94\u7528mRNA-1273\u75ab\u82d7\u5e94\u5bf9\u51a0\u72b6\u75c5\u6bd2\u6050\u5413\u4e3e\u884c\u4e00\u98791\u671f\u7b79\u8bae\u7684\u5984\u5ff5\uff0c\u800cModerna\u5df2\u7b56\u52a8\u7528\u4e8e\u4e34\u5e8a\u5206\u5a29\u3002\u8be5\u6279\u6b21\u7684\u5206\u5a29\u7531\u65f6\u9ae6\u75c5\u9632\u5fa1\u7acb\u5f02\u540c\u76df\uff08CEPI\uff09\u8d44\u52a9\u3002<\/p>\n
2020\u5e742\u67087\u65e5\uff0c\u544a\u7ae3\u4e86\u7b2c\u4e00\u6279\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u5e2d\u5377\u5c0f\u74f6\u7684\u586b\u5145\u548c\u544a\u7ae3\uff0c\u4ece\u5e8f\u5217\u62e3\u9009\u5230\u75ab\u82d7\u5206\u5a29\u5171\u8ba125\u5929\u3002\u7136\u540e\u5c06\u8be5\u6279\u6b21\u4e3e\u884c\u8ba4\u8bc6\u6d4b\u8bd5\u4ee5\u5f00\u91ca\u3002<\/p>\n
2020\u5e742\u670824\u65e5\uff0c\u8be5\u4e34\u5e8a\u6279\u6b21\u4eceModerna\u8fd0\u9001\u5230NIH\uff0c\u7528\u4e8e\u51761\u671f\u4e34\u5e8a\u7b79\u8bae\u3002<\/p>\n
2020\u5e743\u67084\u65e5\uff0c\u7f8e\u90a6\u98df\u7269\u836f\u54c1\u76d1\u89c6\u7ecf\u7ba1\u5c40\uff08FDA\uff09\u544a\u7ae3\u4e86\u5bf9NIH\u9488\u5bf9mRNA-1273\u7684\u7b79\u8bae\u7528\u65b0\u836f\uff08IND\uff09\u7533\u8bf7\u7684\u5ba1\u67e5\uff0c\u5e76\u7b54\u5e94\u8be5\u7b79\u8bae\u8fde\u63a5\u4e3e\u884c\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n
2020\u5e743\u670816\u65e5\uff0cNIH\u516c\u544a\u5df2\u5bf9mRNA-1273\u7684\u7b2c1\u671f\u7b79\u8bae\u7684\u9996\u4f4d\u51fa\u5e2d\u8005\u7ed9\u836f\uff0c\u4ece\u5e8f\u5217\u62e3\u9009\u5230\u521d\u5ea6\u4eba\u7c7b\u7ed9\u836f\u517163\u5929\u3002\u8fd9\u98791\u671f\u7b79\u8bae\u5c06\u4f9b\u7ed9\u76f8\u5408mRNA-1273\u7684\u5b89\u7136\u6027\u548c\u514d\u75ab\u539f\u6027\u7684\u7d27\u6025\u6570\u636e\u3002\u514d\u75ab\u539f\u6027\u662f\u6307\u75ab\u82d7\u8bf1\u5bfc\u51fa\u5e2d\u8005\u514d\u75ab\u54cd\u5e94\u7684\u672c\u9886\u3002\u8fd9\u9879\u7efd\u653e\u6027\u8bd5\u9a8c\u4f30\u8ba1\u5c06\u6b63\u5728\u5927\u7ea6\u516d\u5468\u5185\u62db\u52df45\u540d18\u81f355\u5c81\u7684\u5f3a\u5065\u6210\u4eba\u62b1\u8d1f\u8005\u3002<\/p>\n
2020\u5e743\u670823\u65e5\uff0cModerna\u63d0\u4ea4\u4e86\u6700\u65b0\u9648\u8ff0\uff0c\u4e2a\u4e2d\u5e2d\u5377\u76f8\u5408\u5f97\u5230\u9488\u5bf9COVID-19\u7684\u75ab\u82d7\u7684\u6f5c\u6b63\u5728\u673a\u7f18\u7684\u65b0\u95fb\u3002\u8be5\u516c\u53f8\u9648\u8ff0\u8bf4\uff0c\u7b2c\u4e00\u9636\u6bb5\u7b79\u8bae\u6b63\u6b63\u5728\u9075\u5b88\u8d5e\u540c\u6b63\u5728NIAID\u7684\u8bf1\u5bfc\u4e0b\u4e3e\u884c\u3002\u8be5\u516c\u53f8\u8fdb\u4e00\u6b65\u9648\u8ff0\u8bf4\uff0c\u56fa\u7136\u5e02\u552e\u75ab\u82d7\u4e0d\u884c\u591f\u6b63\u5728\u8d77\u780112-18\u4e2a\u6708\u5185\u4e0a\u5e02\uff0c\u4f46\u6b63\u5728\u9051\u6025\u5e94\u7528\u5883\u51b5\u4e0b\uff0c\u6709\u80fd\u591f\u6b63\u57282020\u5e74\u79cb\u5b63\u5411\u67d0\u4e9b\u4eba\uff08\u5e2d\u5377\u533b\u7597\u4fdd\u5065\u4e13\u4e1a\u804c\u5458\uff09\u4f9b\u7ed9\u75ab\u82d7\u3002\u4efb\u4f55\u9051\u6025\u5e94\u7528\u5747\u5e94\u5f97\u5230\u76f8\u5b9c\u7684\u7981\u9522\u673a\u6784\u7684\u540c\u610f\uff0c\u57fa\u4e8e\u6620\u73b0\u7684mRNA-1273\u4e34\u5e8a\u6570\u636e\u5c06\u52a9\u52a9\u6b63\u5728\u8bb8\u53ef\u4e4b\u524d\u5e94\u7528\u75ab\u82d7\u3002\u5176\u4f59\uff0c\u8be5\u516c\u53f8\u8bf4\u660e\uff0c\u5b83\u6b63\u6b63\u5728\u5938\u5927\u5206\u5a29\u672c\u9886\u3002\u5982\u4e4b\u524d\u6240\u62ab\u9732\u7684\uff0c\u6bcf\u6708\u5206\u5a29\u6570\u767e\u4e07\u5242\u7684\u672c\u9886\u53d6\u51b3\u4e8e\u5938\u5927\u8303\u56f4\u6295\u8d44\u4ee5\u53ca\u516c\u53f8\u73b0\u6709\u6210\u7acb\u6839\u672c\u6b65\u9aa4\u7684\u8fdb\u4e00\u6b65\u6269\u4fee\u3002<\/p>\n
\u4f9d\u7167Moderna\u672c\u4eba\u7684\u5148\u5bb9\uff0c\u5176\u751f\u610f\u6f5c\u5fc3\u4e8e\u5f00\u91c7\u53ef\u7528\u4e8e\u4f17\u79cd\u75be\u75c5\u548c\u75c5\u75c7\u7684mRNA\u836f\u7269\u3002\u5e2d\u5377\u533b\u6cbb\u6d41\u884c\u75c7\u3001\u764c\u75c7\u3001\u7f55\u7779\u75be\u75c5\u548c\u8840\u6c57\u7ba1\u75be\u75c5\u7684\u65b0\u578bmRNA\u836f\u7269\uff0c\u4f46\u76ee\u524d\u6ca1\u6709\u836f\u7269\u83b7\u6279\u4e0a\u5e02\u3002<\/p>\n
mRNA\u662f\u65b0\u5174\u7684\u5e73\u53f0\u3002\u6b63\u5728\u8fc7\u53bb\u7684\u51e0\u5e74\u4e2d\uff0c\u54b1\u4eec\u4f9d\u7136\u6b63\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u8bc1\u5b9e\u4e86\u5176\u6b63\u5728\u8d85\u51fa1,000\u540d\u53d7\u8bd5\u8005\u4e2d\u7684\u75ab\u82d7\u6f5c\u529b\u3002\u8fd9\u5e2d\u5377\u9488\u5bf9\u5176\u4ed6\u4e94\u79cd\u547c\u5438\u9053\u75c5\u6bd2\uff08\u4e24\u79cd\u5927\u65f6\u9ae6\u6027\u6d41\u611f\u75c5\u6bd2\u682a\uff0cRSV\uff0chMPV\u548cPIV3\uff09\u83b7\u80dc\u7684\u65e9\u671f\uff08\u9636\u6bb51\uff09\u4e34\u5e8a\u8bd5\u9a8c\u3002\u6b63\u5728\u8fc7\u53bb\u7684\u56db\u5e74\u4e2d\uff0c\u54b1\u4eec\u4f9d\u7136\u9488\u5bf9mRNA\u75ab\u82d7\u542f\u52a8\u4e869\u9879\u4e34\u5e8a\u8bd5\u9a8c\u3002\u4e0d\u8fc7\uff0c\u52a1\u5fc5\u5938\u5927\u7684\u662f\uff0c\u54b1\u4eec\u8fd8\u5904\u4e8e\u65e9\u671f\u3002\u54b1\u4eec\u6700\u8fdb\u6b65\u7684\u75ab\u82d7\u94fa\u6392\uff08CMV\uff09\u5904\u4e8e2\u671f\u4e34\u5e8a\u6d4b\u8bd5\u4e2d\uff0c\u8fc4\u4eca\u4e3a\u6b62\u54b1\u4eec\u8fd8\u6ca1\u6709\u540c\u610f\u7684\u836f\u7269\u3002<\/p>\n
\u54b1\u4eec\u4e4b\u524d\u66fe\u4e0eNIH\u56e2\u7ed3\u5f00\u91c7\u4e86\u9488\u5bf9MERS-CoV\u7684\u75ab\u82d7\uff0c\u8be5\u75ab\u82d7\u662f\u4e0e\u76ee\u524d\u5927\u65f6\u9ae6\u5206\u522b\u7684\u4e00\u79cd\u51a0\u72b6\u75c5\u6bd2\u3002\u597d\u5bd3\u610f\u7684\u5546\u6807\u540d\u5b57\u5927\u5168\u5c3d\u91cf\u8be5\u5e8f\u6b21\u8fd8\u5904\u4e8e\u7b79\u8bae\u9636\u6bb5\uff0c\u4f46\u6b63\u5728\u54b1\u4eec\u4e3amRNA-1273\u5c55\u5f00\u7b79\u8bae\u65f6\uff0c\u5b83\u4f9b\u7ed9\u4e86\u7d27\u6025\u7684\u7779\u5730\u3002\u6b63\u5728\u5bf9mRNA-1273\u4e3e\u884c1\u671f\u7b79\u8bae\u4e4b\u524d\uff0c\u54b1\u4eec\u4e4b\u524d\u5c1a\u672a\u6b63\u5728\u4eba\u7c7b\u4e2d\u6d4b\u8bd5\u8fc7\u51a0\u72b6\u75c5\u6bd2\u75ab\u82d7\u3002<\/p>\n
mRNA\u662f\u4e00\u4e2a\u65b0\u95fb\u5206\u5b50\uff0c\u54b1\u4eec\u5e94\u7528\u75c5\u6bd2\u7684\u5e8f\u5217\u800c\u4e0d\u662f\u901a\u8fc7\u5bf9\u75c5\u6bd2\u81ea\u5df1\u7684\u6548\u7528\u6765\u7b56\u753b\u54b1\u4eec\u7684mRNA\u75ab\u82d7\u3002\u54b1\u4eec\u7684mRNA\u5e73\u53f0\u6b63\u5728\u6839\u672c\u79d1\u5b66\uff0c\u6210\u7acb\u548c\u4e34\u5e8a\u5f00\u91c7\u65b9\u9762\u6b63\u5728\u901f\u7387\u548c\u6548\u80fd\u4e0a\u5747\u5177\u6709\u663e\u7740\u4e0a\u98ce\u3002<\/p>\n
Moderna\u76ee\u524d\u6b63\u5728\u5176\u9632\u5fa1\u6027\u75ab\u82d7\u82b1\u5f0f\u4e2d\u67099\u4e2a\u5f00\u91c7\u5019\u9009\u5bf9\u8c61\u3002\u8fc4\u4eca\u4e3a\u6b62\uff0cModerna\u5df2\u663e\u73b0\u51fa\u9488\u5bf96\u79cd\u9632\u5fa1\u6027\u75ab\u82d7\uff08H10N8\uff0cH7N9\uff0cRSV\uff0c\u57fa\u5b54\u80af\u96c5\u75c5\u6bd2\uff0chMPV \/ PIV3\u548cCMV\uff09\u7684\u9633\u60271\u671f\u6570\u636e\u8bfb\u6570\u3002<\/p>\n
\u5bf9\u4ed8mRNA-1273\uff0c\u54b1\u4eec\u53ef\u4ee5\u8fd0\u7528\u54b1\u4eec\u6b63\u5728\u75ab\u82d7\u65b9\u9762\u7684\u5c65\u5386\u6025\u8fc5\u4e3e\u884c1\u671f\u4e34\u5e8a\u8bd5\u9a8c\u539f\u6599\u7684\u7b56\u753b\u548c\u6210\u7acb\u3002\u8fd9\u5e2d\u5377\u54b1\u4eec\u8fc4\u4eca\u4e3a\u6b62\u5bf91,000\u4f17\u4e2a\u4e3b\u65e8\u5bf9\u5e73\u53f0\u5b89\u7136\u6027\u7684\u666e\u904d\u6e05\u695a\u3002\u54b1\u4eec\u8fd8\u53d7\u76ca\u4e8e\u54b1\u4eec\u7f8e\u6ee1\u7684\u6210\u7acb\u672c\u9886\uff0c\u6b63\u5728\u8fc7\u53bb\u7684\u4e24\u5e74\u4e2d\uff0c\u8be5\u672c\u9886\u5206\u5a29\u4e86100\u6279\u7528\u4e8e\u4eba\u7c7b\u4e34\u5e8a\u8bd5\u9a8c\u7684mRNA\u836f\u7269\u3002<\/p>\n
NIH\u6b63\u6b63\u5728\u8fd0\u8f6c\u7684\u8bd5\u9a8c\u76841\u671f\u5b89\u7136\u6027\u548c\u514d\u75ab\u539f\u6027\u6570\u636e\u5e0c\u671b\u8bf1\u5bfc\u54b1\u4eec\u7684\u4e0b\u4e00\u6b65\u3002\u9274\u4e8e\u8fd9\u79cd\u5927\u65f6\u9ae6\uff0c\u54b1\u4eec\u4f9d\u7136\u6700\u5148\u5e76\u884c\u5c55\u5f00\u505a\u4e8b\uff0c\u4ee5\u8d1f\u4ed4\u80a9\u7684\u529e\u6cd5\u63a8\u52a8\u8fdb\u4e00\u6b65\u53d1\u8fbe\u3002<\/p>\n
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Moderna\u4f9d\u7136\u6700\u5148\u4e3a\u654f\u6377\u5347\u9ad8\u5176\u6210\u7acb\u672c\u9886\u505a\u9884\u5907\uff0c\u5047\u82e5mRNA-1273\u88ab\u8bc1\u5b9e\u662f\u5b89\u7136\u7684\u5e76\u5177\u6709\u9884\u671f\u7684\u6536\u76ca\uff0c\u90a3\u4e48\u5b83\u80fd\u591f\u7b54\u5e94\u5f02\u65e5\u6210\u7acb\u6570\u767e\u4e07\u5242\u3002\u54b1\u4eec\u4f1a\u5168\u5929\u5019\u505a\u4e8b\uff0c\u4ee5\u786e\u4fdd\u5c3d\u75be\u666e\u904d\u5730\u4f9b\u7ed9\u75ab\u82d7\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"
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